Research Training Group EpiSignal

Epigenomic chromatin modifications and regulatory cell signaling networks are closely linked and essential for the control of cellular responses to external signals, but are often studied separately. EpiSignal research investigates the interplay of these regulatory networks and the consequences of this crosstalk on normal cellular responses and disease development.

At the molecular level, EpiSignal aims to decipher how cell signaling systems regulate chromatin-modifying enzymes and epigenome processes and, conversely, how epigenome systems influence the activity of cellular signaling networks. EpiSignal research will make important contributions to the understanding of the regulation of cell differentiation and proliferation, shed new light on the complex cell and epigenome signaling systems and provide insights into disease processes.

Based on the requirements of cutting-edge research in this emerging biomedical field, EpiSignal will establish an interdisciplinary training program that offers innovative training in all relevant disciplines (cell biology, biochemistry, molecular (epi)genetics and systems biology) and optimally prepares doctoral researchers for future career paths in academia or industry.

To ensure interdisciplinary training, each doctoral researcher is jointly supervised by two principal investigators from different research fields. EpiSignal will create an individual, balanced training program for scientific and transferable skills for each doctoral candidate.

The EpiSignal qualification program includes interdisciplinary lecture series and workshops, regular scientific seminars with progress and paper presentations, annual retreats with international visiting scientists, tech schools with peer-to-peer training in advanced methods, training in transferable skills, lab visits abroad, industrial internships and conference participation. On this basis, EpiSignal will offer:

• A contemporary and innovative research program that offers outstanding doctoral topics and excellent experimental and theoretical training in the relevant disciplines

• Acquisition of interdisciplinary skills through tailored qualification programs and early involvement of doctoral students in independent research

• Excellent and individual supervision with the aim of providing each doctoral candidate with the best possible individual training

• Development of doctoral candidates' skills as task-oriented scientists to become responsible researchers

Thus, EpiSignal doctoral students receive a unique, interdisciplinary education in an emerging field of biomedical research that provides them with all the necessary skills to pursue a successful career in academia or industry.